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Effects of 12 Wk of Omega-3 Fatty Acid Supplementation in Long-Distance Runners.

PMID 36161864 (2023): omega, fatty — Running economy (study note for endurance athletes).

Last updated/Feb 23, 2026, 11:13 PM

Study note • PMID 36161864

Effects of 12 Wk of Omega-3 Fatty Acid Supplementation in Long-Distance Runners.

Medicine and science in sports and exercise2023 • DOI 10.1249/MSS.0000000000003038
Evidence C56/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

This study aimed to investigate the effects of 12 wk of omega-3 fatty acid supplementation during endurance training on omega-3 index (O3I) and indicators of running performance in amateur… (controlled study; n=14 runners).

The abstract suggests a positive effect on Running economy under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: This study aimed to investigate the effects of 12 wk of omega-3 fatty acid supplementation during endurance training on omega-3 index (O3I) and indicators of running performance in amateur…
  • The abstract suggests a positive effect on Running economy under the tested conditions.
  • Population: n=14 runners.
  • Protocol cues (title/abstract): 2234 mg • 916 mg • 4000 mg.

Protocol

Protocol (as reported)

  • Intervention/exposure: omega, fatty (vs placebo).
  • Dose/time/duration cues in abstract/title: 2234 mg • 916 mg • 4000 mg.
  • Outcomes: Running economy.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (n=14 runners) working on biomechanics.
  • Athletes who can measure Running economy with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: controlled study (placebo-controlled).
  • Population: n=14 runners.
  • Comparator: placebo.
  • Outcomes measured: Running economy.
  • Protocol cues mentioned: 2234 mg • 916 mg • 4000 mg.
  • Source: PubMed PMID 36161864 (2023) — Medicine and science in sports and exercise.

Results excerpt

What the abstract reports

O3I was significantly increased in the OMEGA group (from 5.8% to 11.6%, P < 0.0001).

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources