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Study note

Acute Co-Ingestion of Caffeine and Sodium Bicarbonate on Muscular Endurance Performance.

PMID 39771003 (2024): caffeine, bicarbonate — Time-trial performance, Time to exhaustion (study note for endurance athletes).

Updated Jul 22, 2026

Read the study note

Study note • PMID 39771003

Acute Co-Ingestion of Caffeine and Sodium Bicarbonate on Muscular Endurance Performance.

Nutrients2024 • DOI 10.3390/nu16244382

How to use this page

This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.

  • Design signal: randomized trial.
  • Population relevance: athlete/trained context.
  • Consistency: single-study evidence.
  • Practical recommendation depends on tolerance, context, and whether it protects training consistency.

ELI5

In plain language

This study aimed to evaluate the acute effects of co-ingesting caffeine and sodium bicarbonate on muscular endurance at different loads in bench press and back squat exercises. (randomized trial; trained participants).

The abstract suggests a positive effect on Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: This study aimed to evaluate the acute effects of co-ingesting caffeine and sodium bicarbonate on muscular endurance at different loads in bench press and back squat exercises.
  • The abstract suggests a positive effect on Time-trial performance under the tested conditions.
  • Population: trained participants.
  • Protocol cues (title/abstract): 0.3 g/kg • 3 mg/kg.

Protocol

Protocol (as reported)

  • Intervention/exposure: caffeine, bicarbonate (vs placebo).
  • Dose/time/duration cues in abstract/title: 0.3 g/kg • 3 mg/kg.
  • Outcomes: Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it may help, and who should be cautious

Who it helps

  • Athletes similar to the study population (trained participants) working on supplements.
  • Athletes who can measure Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should be cautious

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (double-blind, placebo-controlled).
  • Population: trained participants.
  • Comparator: placebo.
  • Outcomes measured: Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 0.3 g/kg • 3 mg/kg.
  • Source: PubMed PMID 39771003 (2024) — Nutrients.

Results excerpt

What the abstract reports

CAF increased the number of repetitions (p < 0.001; eta(p)(2) = 0.111), mean velocity (V(mean), p = 0.043, eta(p)(2) = 0.16), and mean power output (W(mean), p = 0.034, eta(p)(2) = 0.15) compared to placebo.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations and bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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