Acute Co-Ingestion of Caffeine and Sodium Bicarbonate on Muscular Endurance Performance.

Study note • PMID 39771003

Acute Co-Ingestion of Caffeine and Sodium Bicarbonate on Muscular Endurance Performance.

ELI5

In plain language

Takeaways

What the abstract suggests

• • Study question: This study aimed to evaluate the acute effects of co-ingesting caffeine and sodium bicarbonate on muscular endurance at different loads in bench press and back squat exercises.
• • Results section: no clear change in Time-trial performance, Time to exhaustion under the tested conditions.
• • Population: n=24 trained participants.
• • Protocol cues (full paper): 8.0 mg/kg • 0.3 g/kg • 3 mg/kg • 0.15 g/kg • 1.5 mg/kg • 4 days.

Protocol

Protocol (as reported)

• • Intervention/exposure: caffeine, bicarbonate (vs placebo).
• • Dose/time/duration cues found in the full paper: 8.0 mg/kg • 0.3 g/kg • 3 mg/kg • 0.15 g/kg • 1.5 mg/kg • 4 days • 6 days • 24 h.
• • Outcomes: Time-trial performance, Time to exhaustion.
• • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Methods

What the study actually did

• • Design: randomized trial (randomized, double-blind, placebo-controlled, crossover).
• • Population: n=24 trained participants.
• • Comparator: placebo.
• • Outcomes measured: Time-trial performance, Time to exhaustion.
• • Protocol cues mentioned: 0.3 g/kg • 3 mg/kg.
• • Source: PubMed PMID 39771003 (2024) — Nutrients.

Full paper

What the full paper adds

• • Design features (paper): randomized, double-blind, placebo-controlled, crossover.
• • Participants (paper): n=24 trained participants.
• • More protocol detail (paper): 8.0 mg/kg • 0.3 g/kg • 3 mg/kg • 0.15 g/kg • 1.5 mg/kg • 4 days • 6 days • 24 h.
• • Results section: no clear change in Time-trial performance, Time to exhaustion under the tested conditions.

Results excerpt

What the abstract reports

“CAF increased the number of repetitions (p < 0.001; eta(p)(2) = 0.111), mean velocity (V(mean), p = 0.043, eta(p)(2) = 0.16), and mean power output (W(mean), p = 0.034, eta(p)(2) = 0.15) compared to placebo.”

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

• • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
• • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
• • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
• • This is performance information, not medical advice.