Study note • PMID 37565450
Acute Ingestion of a Ketone Monoester without Co-ingestion of Carbohydrate Improves Running Economy in Male Endurance Runners.
How to use this page
This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.
- • Design signal: randomized trial.
- • Population relevance: mixed/unclear athlete specificity.
- • Consistency: single-study evidence.
- • Practical recommendation depends on tolerance, context, and whether it protects training consistency.
ELI5
In plain language
Acute ingestion of a ketone monoester, with and without co-ingestion of carbohydrate, was investigated for effects on running economy (RE), time to exhaustion (TTE), and other related indices of… (randomized trial; runners).
The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.
Takeaways
What the abstract suggests
- • Study question: Acute ingestion of a ketone monoester, with and without co-ingestion of carbohydrate, was investigated for effects on running economy (RE), time to exhaustion (TTE), and other related indices of…
- • The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions.
- • Population: runners.
- • Protocol cues (title/abstract): 750 mg • 8 min • 14 km.
Protocol
Protocol (as reported)
- • Intervention/exposure: carbohydrate, carb (vs placebo).
- • Dose/time/duration cues in abstract/title: 750 mg • 8 min • 14 km.
- • Outcomes: Time to exhaustion, Time-trial performance, Fat oxidation.
- • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.
Fit
Who it may help, and who should be cautious
Who it helps
- • Athletes similar to the study population (runners) working on fueling.
- • Athletes who can measure Time to exhaustion, Time-trial performance, Fat oxidation with a repeatable workout or time-trial effort.
Who should be cautious
- • If you have symptoms or conditions that make the intervention risky, get professional guidance.
- • If you’re near race day and can’t safely test, defer the experiment.
Methods
What the study actually did
- • Design: randomized trial (placebo-controlled).
- • Population: runners.
- • Comparator: placebo.
- • Outcomes measured: Time to exhaustion, Time-trial performance, Fat oxidation.
- • Protocol cues mentioned: 750 mg • 8 min • 14 km.
- • Source: PubMed PMID 37565450 (2024) — Medicine and science in sports and exercise.
Results excerpt
What the abstract reports
“RE was lower at each submaximal running speed (effect size = 0.48-0.98) by an average of 4.1% in KE compared with CHO, but not between CHO + KE and CHO.”
Note: excerpts are short; for full context, read the paper.
Limits
Limitations and bias
- • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
- • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
- • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
- • This is performance information, not medical advice.
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