Study note • PMID 37565450
Acute Ingestion of a Ketone Monoester without Co-ingestion of Carbohydrate Improves Running Economy in Male Endurance Runners.
Worth trying if it fits your goal and context.
ELI5
In plain language
Acute ingestion of a ketone monoester, with and without co-ingestion of carbohydrate, was investigated for effects on running economy (RE), time to exhaustion (TTE), and other related indices of… (randomized trial; runners).
The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.
Takeaways
What the abstract suggests
- • Study question: Acute ingestion of a ketone monoester, with and without co-ingestion of carbohydrate, was investigated for effects on running economy (RE), time to exhaustion (TTE), and other related indices of…
- • The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions.
- • Population: runners.
- • Protocol cues (title/abstract): 750 mg • 8 min • 14 km.
Protocol
Protocol (as reported)
- • Intervention/exposure: carbohydrate, carb (vs placebo).
- • Dose/time/duration cues in abstract/title: 750 mg • 8 min • 14 km.
- • Outcomes: Time to exhaustion, Time-trial performance, Fat oxidation.
- • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.
Fit
Who it helps, and who should skip it
Who it helps
- • Athletes similar to the study population (runners) working on fueling.
- • Athletes who can measure Time to exhaustion, Time-trial performance, Fat oxidation with a repeatable workout or time-trial effort.
Who should skip
- • If you have symptoms or conditions that make the intervention risky, get professional guidance.
- • If you’re near race day and can’t safely test, defer the experiment.
Methods
What the study actually did
- • Design: randomized trial (placebo-controlled).
- • Population: runners.
- • Comparator: placebo.
- • Outcomes measured: Time to exhaustion, Time-trial performance, Fat oxidation.
- • Protocol cues mentioned: 750 mg • 8 min • 14 km.
- • Source: PubMed PMID 37565450 (2024) — Medicine and science in sports and exercise.
Results excerpt
What the abstract reports
“RE was lower at each submaximal running speed (effect size = 0.48-0.98) by an average of 4.1% in KE compared with CHO, but not between CHO + KE and CHO.”
Note: excerpts are short; for full context, read the paper.
Limits
Limitations & bias
- • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
- • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
- • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
- • This is performance information, not medical advice.
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