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How Repeatable Is the Ergogenic Effect of Caffeine? Limited Reproducibility of Acute Caffeine (3 mg.kg(-1)) Ingestion on Muscular Strength, Power, and Muscular Endurance.

PMID 36297102 (2022): caffeine — Time-trial performance, Time to exhaustion (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 36297102

How Repeatable Is the Ergogenic Effect of Caffeine? Limited Reproducibility of Acute Caffeine (3 mg.kg(-1)) Ingestion on Muscular Strength, Power, and Muscular Endurance.

Nutrients2022 • DOI 10.3390/nu14204416
Evidence C69/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

This study aimed to determine the effect of 3 mg.kg-1 acute caffeine ingestion on muscular strength, power and strength endurance and the repeatability of potential ergogenic effects across multiple trials. (randomized trial; participants).

The abstract suggests a positive effect on Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: This study aimed to determine the effect of 3 mg.kg-1 acute caffeine ingestion on muscular strength, power and strength endurance and the repeatability of potential ergogenic effects across multiple trials.
  • The abstract suggests a positive effect on Time-trial performance under the tested conditions.
  • Population: participants.
  • Protocol cues (title/abstract): 3 mg.

Protocol

Protocol (as reported)

  • Intervention/exposure: caffeine (vs placebo).
  • Dose/time/duration cues in abstract/title: 3 mg.
  • Outcomes: Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (participants) working on supplements.
  • Athletes who can measure Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (double-blind, placebo-controlled).
  • Population: participants.
  • Comparator: placebo.
  • Outcomes measured: Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 3 mg.
  • Source: PubMed PMID 36297102 (2022) — Nutrients.

Results excerpt

What the abstract reports

When individual caffeine trials were compared to corresponding placebo trials, effect sizes ranged from trivial-large favoring caffeine irrespective of a main effect of treatment being identified in the ANOVA.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources