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Study note

Tracing the lactate shuttle to the mitochondrial reticulum.

Updated Oct 17, 2026

Human researchExperimental & molecular medicine2022Read the source on PubMed

What the study found

The review explains lactate exchange between organs, cells and cellular compartments, supporting its role as an energy substrate rather than merely a waste product.

Participants and protocol

The article synthesizes isotope-tracer, blood-flow and tissue-measurement research underlying lactate-shuttle theory.

What this cannot establish

Mechanistic physiology does not identify an individual's threshold pace or show that a particular workout or lactate supplement improves racing. Training prescriptions require separate evidence.

Publication details
Record
PubMed 36075947
Publication types
review-article · Review · Research Support, N.I.H., Extramural
Indexed subjects
Muscle, Skeletal · Mitochondria · Glycerol · Lactic Acid · Glucose
Source record checked
2026-10-18

Publication type and subject indexing describe the record; they are not a quality grade or proof of a benefit. An abstract does not replace a review of the full methods and results.

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