Skip to content

Study note

Caffeine ingestion increases endurance performance of trained male cyclists when riding against a virtual opponent without altering muscle fatigue.

PMID 35612684 (2022): caffeine — Time-trial performance, Time to exhaustion (study note for endurance athletes).

Updated Jul 22, 2026

Read the study note

Study note • PMID 35612684

Caffeine ingestion increases endurance performance of trained male cyclists when riding against a virtual opponent without altering muscle fatigue.

European journal of applied physiology2022 • DOI 10.1007/s00421-022-04969-5

How to use this page

This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.

  • Design signal: randomized trial.
  • Population relevance: athlete/trained context.
  • Consistency: single-study evidence.
  • Practical recommendation depends on tolerance, context, and whether it protects training consistency.

ELI5

In plain language

Caffeine improves cycling time trial (TT) performance; however, it is unknown whether caffeine is ergogenic when competing against other riders. (randomized trial; well-trained cyclists).

The abstract doesn’t indicate a clear change in Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: Caffeine improves cycling time trial (TT) performance; however, it is unknown whether caffeine is ergogenic when competing against other riders.
  • The abstract doesn’t indicate a clear change in Time-trial performance under the tested conditions.
  • Population: well-trained cyclists.
  • Protocol cues (title/abstract): 5 mg • 2 km.

Protocol

Protocol (as reported)

  • Intervention/exposure: caffeine (vs placebo).
  • Dose/time/duration cues in abstract/title: 5 mg • 2 km.
  • Outcomes: Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it may help, and who should be cautious

Who it helps

  • Athletes similar to the study population (well-trained cyclists) working on supplements.
  • Athletes who can measure Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should be cautious

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (double-blind, placebo-controlled).
  • Population: well-trained cyclists.
  • Comparator: placebo.
  • Outcomes measured: Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 5 mg • 2 km.
  • Source: PubMed PMID 35612684 (2022) — European journal of applied physiology.

Results excerpt

What the abstract reports

Compared to CON, OP-PLA improved 4-km cycling TT performance (P = 0.018), and OP-CAF further improved performance when compared to OP-PLA (P = 0.050).

Note: excerpts are short; for full context, read the paper.

Limits

Limitations and bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

Adaptive AI coach for iPhone

Meet your adaptive AI coach.

Tell your coach what you are training for. It builds the plan, follows the work you complete, and adapts upcoming training when recovery, your schedule, or real life changes.

Keep going

Sources