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Effect of carbohydrate ingestion on exercise endurance and metabolism after a 1-day fast.

PMID 3246466 (1988): carbohydrate, carb — Time to exhaustion, Time-trial performance, Fat oxidation (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 3246466

Effect of carbohydrate ingestion on exercise endurance and metabolism after a 1-day fast.

International journal of sports medicine1988 • DOI 10.1055/s-2007-1025032
Evidence C67/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

Fasting before an exercise event has been demonstrated to decrease endurance. (randomized trial; participants).

The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: Fasting before an exercise event has been demonstrated to decrease endurance.
  • The abstract doesn’t indicate a clear change in Time to exhaustion, Time-trial performance under the tested conditions.
  • Population: participants.
  • Protocol cues (title/abstract): 21 h • 8 min • 40 min • 70% VO2max.

Protocol

Protocol (as reported)

  • Intervention/exposure: carbohydrate, carb (vs placebo).
  • Dose/time/duration cues in abstract/title: 21 h • 8 min • 40 min • 70% VO2max.
  • Outcomes: Time to exhaustion, Time-trial performance, Fat oxidation.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (participants) working on fueling.
  • Athletes who can measure Time to exhaustion, Time-trial performance, Fat oxidation with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (placebo-controlled).
  • Population: participants.
  • Comparator: placebo.
  • Outcomes measured: Time to exhaustion, Time-trial performance, Fat oxidation.
  • Protocol cues mentioned: 21 h • 8 min • 40 min • 70% VO2max.
  • Source: PubMed PMID 3246466 (1988) — International journal of sports medicine.

Results excerpt

What the abstract reports

This seemed to be confirmed by the significantly lower plasma glycerol concentration, which suggested less fat mobilization in the CHO trial.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources