Skip to content

Effect of caffeine on neuromuscular function following eccentric-based exercise.

PMID 31697729 (2019): caffeine — Time-trial performance, Time to exhaustion (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 31697729

Effect of caffeine on neuromuscular function following eccentric-based exercise.

PloS one2019 • DOI 10.1371/journal.pone.0224794
Evidence C69/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

This study investigated the effect of caffeine on neuromuscular function, power and sprint performance during the days following an eccentric-based exercise. (randomized trial; participants).

Effects on Time-trial performance are mixed or unclear from the abstract alone. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: This study investigated the effect of caffeine on neuromuscular function, power and sprint performance during the days following an eccentric-based exercise.
  • Effects on Time-trial performance are mixed or unclear from the abstract alone.
  • Population: participants.
  • Protocol cues (title/abstract): 5 mg • 72 h • 50 min • 75 min • 24 h.

Protocol

Protocol (as reported)

  • Intervention/exposure: caffeine (vs placebo).
  • Dose/time/duration cues in abstract/title: 5 mg • 72 h • 50 min • 75 min • 24 h.
  • Outcomes: Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (participants) working on supplements.
  • Athletes who can measure Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (double-blind, placebo-controlled).
  • Population: participants.
  • Comparator: placebo.
  • Outcomes measured: Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 5 mg • 72 h • 50 min • 75 min • 24 h.
  • Source: PubMed PMID 31697729 (2019) — PloS one.

Results excerpt

What the abstract reports

However, caffeine increased height and power during the vertical countermovement-jump test at 48 and 72 h post half-squat exercise, when compared to the placebo (P < 0.05).

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

Coaching beta

Get a plan that adapts to your life.

Join the 26weeks.ai TestFlight beta for adaptive coaching, recovery-aware adjustments, and race-week reminders.

Keep going

Sources