Study note • PMID 30742692
Association of skeletal muscle and serum metabolites with maximum power output gains in response to continuous endurance or high-intensity interval training programs: The TIMES study - A randomized controlled trial.
Worth trying if it fits your goal and context.
ELI5
In plain language
We investigated baseline serum and skeletal muscle metabolomics profile and its associations with maximal power output (MPO) gains in response to 8-week of continuous endurance training (ET) and high-intensity… (randomized trial; n=30 participants).
The abstract doesn’t indicate a clear change in VO₂max, Lactate threshold under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.
Takeaways
What the abstract suggests
- • Study question: We investigated baseline serum and skeletal muscle metabolomics profile and its associations with maximal power output (MPO) gains in response to 8-week of continuous endurance training (ET) and high-intensity…
- • The abstract doesn’t indicate a clear change in VO₂max, Lactate threshold under the tested conditions.
- • Population: n=30 participants.
- • Protocol cues (title/abstract): 8 weeks.
Protocol
Protocol (as reported)
- • Intervention/exposure: endurance, interval.
- • Dose/time/duration cues in abstract/title: 8 weeks.
- • Outcomes: VO₂max, Lactate threshold.
- • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.
Fit
Who it helps, and who should skip it
Who it helps
- • Athletes similar to the study population (n=30 participants) working on endurance.
- • Athletes who can measure VO₂max, Lactate threshold with a repeatable workout or time-trial effort.
Who should skip
- • If you have symptoms or conditions that make the intervention risky, get professional guidance.
- • If you’re near race day and can’t safely test, defer the experiment.
Methods
What the study actually did
- • Design: randomized trial.
- • Population: n=30 participants.
- • Outcomes measured: VO₂max, Lactate threshold.
- • Protocol cues mentioned: 8 weeks.
- • Source: PubMed PMID 30742692 (2019) — PloS one.
Results excerpt
What the abstract reports
“The exercise programs generated similar gains in MPO (ET = 21.4 +/- 8.0%; HIIT = 24.3 +/- 8.5%).”
Note: excerpts are short; for full context, read the paper.
Limits
Limitations & bias
- • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
- • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
- • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
- • This is performance information, not medical advice.
Coaching beta
Get a plan that adapts to your life.
Join the 26weeks.ai TestFlight beta for adaptive coaching, recovery-aware adjustments, and race-week reminders.
Keep going
Performance Science Lab
Research-backed protocols and evidence grades for endurance performance — built for athletes.
Endurance performance research
Endurance is built by repeatable work you can recover from — not by heroic weeks you can’t sustain.
Caffeine for endurance performance: a practical protocol
Evidence-informed protocol: Caffeine for endurance performance: a practical protocol. Practical steps, who it helps, and what to watch out for.
VO₂max research for endurance athletes
A ceiling metric: useful, but endurance performance is usually limited by durability and pacing.
Lactate threshold research for endurance athletes
Threshold is 'how fast you can go for a long time' — where most endurance races are decided.