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Endurance capacity and neuromuscular fatigue following high- vs moderate-intensity endurance training: A randomized trial.

PMID 28207951 (2017): endurance, interval — VO₂max, Lactate threshold (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 28207951

Endurance capacity and neuromuscular fatigue following high- vs moderate-intensity endurance training: A randomized trial.

Scandinavian journal of medicine & science in sports2017 • DOI 10.1111/sms.12854
Evidence C67/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

High-intensity exercise induces significant central and peripheral fatigue; however, the effect of endurance training on these mechanisms of fatigue is poorly understood. (randomized trial; participants).

The abstract suggests a positive effect on VO₂max, Lactate threshold under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: High-intensity exercise induces significant central and peripheral fatigue; however, the effect of endurance training on these mechanisms of fatigue is poorly understood.
  • The abstract suggests a positive effect on VO₂max, Lactate threshold under the tested conditions.
  • Population: participants.
  • Protocol cues (title/abstract): 6 weeks • 80 minutes.

Protocol

Protocol (as reported)

  • Intervention/exposure: endurance, interval (vs comparison group).
  • Dose/time/duration cues in abstract/title: 6 weeks • 80 minutes.
  • Outcomes: VO₂max, Lactate threshold.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (participants) working on endurance.
  • Athletes who can measure VO₂max, Lactate threshold with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial.
  • Population: participants.
  • Comparator: comparison group.
  • Outcomes measured: VO₂max, Lactate threshold.
  • Protocol cues mentioned: 6 weeks • 80 minutes.
  • Source: PubMed PMID 28207951 (2017) — Scandinavian journal of medicine & science in sports.

Results excerpt

What the abstract reports

Compared with pre-training, HIIT increased the level of potentiated quadriceps twitch reduction (-34% vs -43%, respectively, P=.023) and attenuated the level of voluntary activation reduction (-7% vs -3%, respectively, P=.047) following the TTE trial at the same relative intensity.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources