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Study note

Caffeine improves physical and cognitive performance during exhaustive exercise.

PMID 18799996 (2008): caffeine — Time-trial performance, Time to exhaustion (study note for endurance athletes).

Updated Feb 23, 2026

Read the study note

Study note • PMID 18799996

Caffeine improves physical and cognitive performance during exhaustive exercise.

Medicine and science in sports and exercise2008 • DOI 10.1249/MSS.0b013e31817bb8b7

How to use this page

This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.

  • Design signal: randomized trial.
  • Population relevance: athlete/trained context.
  • Consistency: single-study evidence.
  • Practical recommendation depends on tolerance, context, and whether it protects training consistency.

ELI5

In plain language

To examine the effects of ingesting a performance bar, containing caffeine, before and during cycling exercise on physical and cognitive performance. (randomized trial; well-trained cyclists).

The abstract doesn’t indicate a clear change in Time-trial performance, Time to exhaustion under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: To examine the effects of ingesting a performance bar, containing caffeine, before and during cycling exercise on physical and cognitive performance.
  • The abstract doesn’t indicate a clear change in Time-trial performance, Time to exhaustion under the tested conditions.
  • Population: well-trained cyclists.
  • Protocol cues (title/abstract): 100 mg • 115 min • 140 min • 5 min • 60% VO2max • 75% VO2max.

Protocol

Protocol (as reported)

  • Intervention/exposure: caffeine (vs placebo).
  • Dose/time/duration cues in abstract/title: 100 mg • 115 min • 140 min • 5 min • 60% VO2max • 75% VO2max.
  • Outcomes: Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it may help, and who should be cautious

Who it helps

  • Athletes similar to the study population (well-trained cyclists) working on supplements.
  • Athletes who can measure Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should be cautious

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: randomized trial (placebo-controlled).
  • Population: well-trained cyclists.
  • Comparator: placebo.
  • Outcomes measured: Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 100 mg • 115 min • 140 min • 5 min • 60% VO2max • 75% VO2max.
  • Source: PubMed PMID 18799996 (2008) — Medicine and science in sports and exercise.

Results excerpt

What the abstract reports

Participants were significantly faster after CAF when compared with CHO on both the computerized complex information processing tests, particularly after 140 min and after the T2EX ride (P < 0.001).

Note: excerpts are short; for full context, read the paper.

Limits

Limitations and bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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