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Effects of carbohydrate ingestion before and during exercise on glucose kinetics and performance.

PMID 11090571 (2000): carbohydrate, carb — Time to exhaustion, Time-trial performance, Fat oxidation (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 11090571

Effects of carbohydrate ingestion before and during exercise on glucose kinetics and performance.

Journal of applied physiology (Bethesda, Md. : 1985)2000 • DOI 10.1152/jappl.2000.89.6.2220
Evidence C60/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

We investigated the effect of carbohydrate (CHO) ingestion before and during exercise and in combination on glucose kinetics, metabolism and performance in seven trained men, who cycled for 120… (controlled study; trained participants).

The abstract doesn’t indicate a clear change in Time-trial performance, Fat oxidation under the tested conditions. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: We investigated the effect of carbohydrate (CHO) ingestion before and during exercise and in combination on glucose kinetics, metabolism and performance in seven trained men, who cycled for 120…
  • The abstract doesn’t indicate a clear change in Time-trial performance, Fat oxidation under the tested conditions.
  • Population: trained participants.
  • Protocol cues (title/abstract): 2 g/kg • 120 min • 30 min • 80 min.

Protocol

Protocol (as reported)

  • Intervention/exposure: carbohydrate, carb (vs placebo).
  • Dose/time/duration cues in abstract/title: 2 g/kg • 120 min • 30 min • 80 min.
  • Outcomes: Time to exhaustion, Time-trial performance, Fat oxidation.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (trained participants) working on fueling.
  • Athletes who can measure Time to exhaustion, Time-trial performance, Fat oxidation with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: controlled study (placebo-controlled).
  • Population: trained participants.
  • Comparator: placebo.
  • Outcomes measured: Time to exhaustion, Time-trial performance, Fat oxidation.
  • Protocol cues mentioned: 2 g/kg • 120 min • 30 min • 80 min.
  • Source: PubMed PMID 11090571 (2000) — Journal of applied physiology (Bethesda, Md. : 1985).

Results excerpt

What the abstract reports

Despite this, TT was improved in CC and PC compared with PP (P < 0.05).

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources