Study note • PMID 40845293
Effects of Caffeine Supplementation on Neuromuscular Performance in Powerlifting Athletes: A Randomized, Placebo-Controlled, Quadruple-Blinded, Cross-Over Study.
How to use this page
This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.
- • Design signal: randomized trial.
- • Population relevance: athlete/trained context.
- • Consistency: single-study evidence.
- • Practical recommendation depends on tolerance, context, and whether it protects training consistency.
ELI5
In plain language
Enes, A, Hubner, P, Oneda, G, Bernardo, MF, Macedo, ACG, Salles, GN, Ferreira, LHB, Rezende, EF, Mohan, AE, Pinero, A, Leonel, DF, Cruz, R, Schoenfeld, BJ, and Souza-Junior, TP. (randomized trial; athletes).
Effects on Time-trial performance are mixed or unclear from the abstract alone. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.
Takeaways
What the abstract suggests
- • Study question: Enes, A, Hubner, P, Oneda, G, Bernardo, MF, Macedo, ACG, Salles, GN, Ferreira, LHB, Rezende, EF, Mohan, AE, Pinero, A, Leonel, DF, Cruz, R, Schoenfeld, BJ, and Souza-Junior, TP.
- • Effects on Time-trial performance are mixed or unclear from the abstract alone.
- • Population: athletes.
- • Protocol cues (title/abstract): 8 mg • 1 week • 60 minutes.
Protocol
Protocol (as reported)
- • Intervention/exposure: caffeine (vs placebo).
- • Dose/time/duration cues in abstract/title: 8 mg • 1 week • 60 minutes.
- • Outcomes: Time-trial performance.
- • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.
Fit
Who it may help, and who should be cautious
Who it helps
- • Athletes similar to the study population (athletes) working on supplements.
- • Athletes who can measure Time-trial performance with a repeatable workout or time-trial effort.
Who should be cautious
- • If you have symptoms or conditions that make the intervention risky, get professional guidance.
- • If you’re near race day and can’t safely test, defer the experiment.
Methods
What the study actually did
- • Design: randomized trial (placebo-controlled).
- • Population: athletes.
- • Comparator: placebo.
- • Outcomes measured: Time-trial performance.
- • Protocol cues mentioned: 8 mg • 1 week • 60 minutes.
- • Source: PubMed PMID 40845293 (2025) — Journal of strength and conditioning research.
Results excerpt
What the abstract reports
“For RPE, there was a main effect of condition where CAF intake led to lower scores for back squat (p = 0.003) and deadlift (p = 0.042).”
Note: excerpts are short; for full context, read the paper.
Limits
Limitations and bias
- • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
- • Single studies often don’t generalize to your event, history, and training load; treat results as a starting point.
- • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
- • This is performance information, not medical advice.
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