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A Review of Carbohydrate Supplementation Approaches and Strategies for Optimizing Performance in Elite Long-Distance Endurance.

PMID 40077786 (2025): altitude — VO₂max, Time-trial performance (study note for endurance athletes).

Last updated/Feb 23, 2026, 10:34 PM

Study note • PMID 40077786

A Review of Carbohydrate Supplementation Approaches and Strategies for Optimizing Performance in Elite Long-Distance Endurance.

Nutrients2025 • DOI 10.3390/nu17050918
Evidence C60/100
Action 2: Consider

Worth trying if it fits your goal and context.

ELI5

In plain language

Carbohydrate supplementation is a common practice among endurance athletes participating in long-distance competitions. (review; n=50 elite runners).

In this review, the abstract suggests a positive relationship with Time-trial performance. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: Carbohydrate supplementation is a common practice among endurance athletes participating in long-distance competitions.
  • In this review, the abstract suggests a positive relationship with Time-trial performance.
  • Population: n=50 elite runners.
  • Protocol cues (full paper): 9 mg • 8 mg • 10 days • 6 days • 60 min • 90 min.

Protocol

Protocol (as reported)

  • Intervention/exposure: altitude.
  • Dose/time/duration cues found in the full paper: 9 mg • 8 mg • 10 days • 6 days • 60 min • 90 min • 24 h • 48 h.
  • Outcomes: VO₂max, Time-trial performance.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it helps, and who should skip it

Who it helps

  • Athletes similar to the study population (n=50 elite runners) working on altitude.
  • Athletes who can measure VO₂max, Time-trial performance with a repeatable workout or time-trial effort.

Who should skip

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: review.
  • Population: n=50 elite runners.
  • Outcomes measured: VO₂max, Time-trial performance.
  • Protocol cues (paper): 9 mg • 8 mg • 10 days • 6 days • 60 min • 90 min • 24 h • 48 h.
  • Source: PubMed PMID 40077786 (2025) — Nutrients.

Full paper

What the full paper adds

  • Participants (paper): n=50 elite runners.
  • More protocol detail (paper): 9 mg • 8 mg • 10 days • 6 days • 60 min • 90 min • 24 h • 48 h.

Results excerpt

What the abstract reports

Carbohydrate supplementation is a common practice among endurance athletes participating in long-distance competitions.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations & bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Reviews and consensus statements mix protocols and populations; recommendations may not match your exact constraints.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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Sources