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Study note

International society of sports nutrition position stand: caffeine and exercise performance.

PMID 33388079 (2021): altitude — VO₂max, Time-trial performance, Time to exhaustion (study note for endurance athletes).

Updated Jul 22, 2026

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Study note • PMID 33388079

International society of sports nutrition position stand: caffeine and exercise performance.

Journal of the International Society of Sports Nutrition2021 • DOI 10.1186/s12970-020-00383-4

How to use this page

This note summarizes one study record. Check the participants, methods, results, and limitations before applying it to training.

  • Design signal: review.
  • Population relevance: athlete/trained context.
  • Consistency: single-study evidence.
  • Practical recommendation depends on tolerance, context, and whether it protects training consistency.

ELI5

In plain language

Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows: 1. (review; trained participants).

In this review, the abstract suggests a positive relationship with Time-trial performance. Treat this as a signal, not a guarantee; confirm methods and context in the full paper.

Takeaways

What the abstract suggests

  • Study question: Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows: 1.
  • In this review, the abstract suggests a positive relationship with Time-trial performance.
  • Population: trained participants.
  • Protocol cues (title/abstract): 6 mg/kg • 2 mg/kg • 9 mg/kg • 3-6 mg/kg • 3 to 6 mg/kg • 4-6 mg/kg.

Protocol

Protocol (as reported)

  • Intervention/exposure: altitude.
  • Dose/time/duration cues in abstract/title: 6 mg/kg • 2 mg/kg • 9 mg/kg • 3-6 mg/kg • 3 to 6 mg/kg • 4-6 mg/kg • 60 min.
  • Outcomes: VO₂max, Time-trial performance, Time to exhaustion.
  • Replication note: abstracts often omit adherence and timing; confirm details before changing training or supplementation.

Fit

Who it may help, and who should be cautious

Who it helps

  • Athletes similar to the study population (trained participants) working on altitude.
  • Athletes who can measure VO₂max, Time-trial performance, Time to exhaustion with a repeatable workout or time-trial effort.

Who should be cautious

  • If you have symptoms or conditions that make the intervention risky, get professional guidance.
  • If you’re near race day and can’t safely test, defer the experiment.

Methods

What the study actually did

  • Design: review.
  • Population: trained participants.
  • Outcomes measured: VO₂max, Time-trial performance, Time to exhaustion.
  • Protocol cues mentioned: 6 mg/kg • 2 mg/kg • 9 mg/kg • 3-6 mg/kg • 3 to 6 mg/kg • 4-6 mg/kg • 60 min.
  • Source: PubMed PMID 33388079 (2021) — Journal of the International Society of Sports Nutrition.

Results excerpt

What the abstract reports

For example, as compared to caffeine capsules, caffeine chewing gums may require a shorter waiting time from consumption to the start of the exercise session.

Note: excerpts are short; for full context, read the paper.

Limits

Limitations and bias

  • Abstract-only summaries can miss critical details (population, protocol, adherence, and context).
  • Reviews and consensus statements mix protocols and populations; recommendations may not match your exact constraints.
  • If your context differs (elite vs recreational; cycling vs running), adjust expectations and be conservative.
  • This is performance information, not medical advice.

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